Pen selection chart
After calculating the appropriate dose, locate that dose in the columns below and then look to the far left to determine the number of doses that a single cartridge may provide. This can help you prescribe the appropriate number of cartridges and let you inform patients how often they will need to change the cartridge in their Pen.
Injection site should be rotated to avoid tissue atrophy. Patients should be informed that local or systemic allergic reactions may occur and that prompt medical attention should be sought in such cases.
Humatrope cartridges must be refrigerated before and after reconstitution.
Humatrope cartridges should not be used if the patient is allergic to metacresol or glycerin, which are components of the Diluent for Humatrope.
*The number of doses provided by a cartridge within this dose range is limited to 28 because a reconstituted cartridge is stable for 28 days when refrigerated.
†The 6 mg cartridge may be more appropriate in this dose range.
ⵐThe 12 mg cartridge may be more appropriate in this dose range.
About the vial and syringe option
- Humatrope is available in a 5 mg vial.
- Each vial is supplied in a combination package with an accompanying 5 mL vial of diluent.
- If sensitivity to the Diluent for Humatrope should occur, the vials may be reconstituted with Bacteriostatic Water for Injection (Benzyl Alcohol preserved), United States Pharmacopoeia (USP) or Sterile Water for Injection, USP.
- When Humatrope is reconstituted with Bacteriostatic Water for Injection, USP, the solution should be kept refrigerated at 36° to 46°F (2° to 8°C) and used within 14 days.
- It is important to note that benzyl alcohol used as a preservative in Bacteriostatic Water has been associated with toxicity in newborns. Therefore, Bacteriostatic Water for Injection must not be used to reconstitute Humatrope for use in a newborn infant. When Humatrope is to be administered to a newborn infant, it should be reconstituted with the diluent provided or, if the infant is sensitive to the diluent, Sterile Water for Injection, USP.
- When reconstituted with Sterile Water for Injection, the solution should be kept refrigerated at 36° to 46°F (2° to 8°C) and used within 24 hours. Use only 1 dose per Humatrope vial and discard the unused portion.
When taking Humatrope (somatropin for injection) remember
Below are some answers to questions you may have about the HumatroPen® 6 mg, 12 mg, and 24 mg injection devices.
See Full Pen User Manual that accompanies the HumatroPen®6mg, 12mg, and 24mg.
- If you miss a dose of Humatrope, you should simply take the next dose at the regularly scheduled time. Do not double up on doses.
- Pen Needles are not included with the HumatroPen® injection device. You may need a prescription to obtain the Needles from your pharmacist.
- BD Pen Needles are suitable for use with the HumatroPen®.
- Ask your healthcare professional what Needle gauge and length is best to use.
- Follow your healthcare professional's instructions on safe handling of Needles.
BD and BD Logo are trademarks of Becton, Dickinson and Company.
- Yes, a new needle must be used for each injection.
- Remove the needle immediately after each injection and discard into a puncture-proof container. Use a new needle for each injection. This will help minimize the risk of infection, prevent leakage of Humatrope, keep out air bubbles, and reduce needle clogs.
- Throw away used needles in a puncture-proof container. Follow your healthcare professional's instructions on how to do this safely. Keep sharps container out of reach of children and pets.
- No. The New Cartridge Setup should be performed only once for each Cartridge, just before a new Cartridge is used for the first time.
- The purpose of the setup is to make sure the HumatroPen® and Cartridge are ready to use.
- If you repeat the New Cartridge Setup before each routine dose, you may run out of Humatrope early. The small amount of product used in the New Cartridge Setup will not affect the supply of Humatrope. Confirm that you have a 6 mg, 12 mg, or 24 mg Humatrope cartridge to match the corresponding HumatroPen®. This is important to ensure the prescribed dose of Humatrope is given. If it does not match, DO NOT USE and call The Lilly Answers Center at 1-800-LillyRX (1-800-545-5979) from 9 AM to 8 PM Eastern time, or call your healthcare professional.
- DO NOT USE the HumatroPen® if the mg number (6 mg, 12 mg, or 24 mg) on the Humatrope Cartridge label does not match the number on the end of the Dose Knob and Front Housing of the HumatroPen®. This is important to ensure the correct dose of Humatrope is given.
- Contact The Lilly Answers Center (1-800-545-5979) or your healthcare professional for assistance or to obtain a replacement HumatroPen.
- Be sure to gently invert the Cartridge up and down 10 times. DO NOT SHAKE. Then, let the Cartridge sit for at least 3 minutes. If the solution remains cloudy or has particles, gently invert the Cartridge up and down 10 more times. Let the Cartridge sit for 5 more minutes.
- If the solution remains cloudy or contains particles after reconstitution (mixing), DO NOT USE. Contact your healthcare professional for assistance.
- Air bubbles may remain in the Cartridge after reconstitution (mixing).
- If the HumatroPen® is stored with a needle attached, air bubbles may form in the Cartridge. DO NOT STORE the HumatroPen® with a needle attached.
- If air bubbles are present, perform the New Cartridge Setup to remove air bubbles from the Cartridge.
- A small air bubble is normal. It will not cause any harm nor affect the dose.
- The Screw may not move out when you push the Injection Button unless there is a Cartridge in the HumatroPen®. This feature allows you to easily push the Screw into the HumatroPen® Body when replacing a Cartridge.
- Once a Cartridge is attached, the Screw will move out when the Injection Button is pushed.
- Check that the Cartridge is not damaged or broken.
- Carefully line up the Cartridge with the HumatroPen® Body and screw together until secure. If the Cartridge and HumatroPen® cannot be screwed together, contact your healthcare professional.
- The Needle may be clogged. Try attaching a new Needle.
- Pushing the Injection Button down quickly may make the Injection Button harder to push. Pushing the Injection Button more slowly may make it easier.
- Using a larger-diameter Needle will make it easier to push the Injection Button during injection. Ask your healthcare professional which Needle is best for you or your child.
- The Injection Button may become harder to push if the inside of the HumatroPen® gets dirty.
- This can happen if the Humatrope Cartridge does not have enough Humatrope left in it for the full dose. It is possible to set a dose larger than the amount of Humatrope left in the Cartridge. At the end of the injection, the number in the Dose Window should be 0.00. If it is not, the number showing in the window is the amount of Humatrope that WAS NOT delivered. Consult with your healthcare professional on how to handle a partial dose. Remove the needle and the empty cartridge. For the next daily use, attach a new Cartridge as shown in the HumatroPen® User Manual, and continue with New Cartridge Setup.
- It is normal for a single drop to remain on the tip of the needle after the injection is complete. If you see more than one drop:
- The full dose may not have been delivered. DO NOT INJECT another dose. Consult with your healthcare professional for assistance.
- To prevent this, for the next dose, firmly push and hold the Injection Button in and slowly count to five.
- The injection is complete when:
- You have slowly counted to five while you are still holding the Injection Button in and before you remove the needle from the skin,
- 0.00 is in the center of the Dose Window.